Equal channel angular pressing is one of the most effective severe plastic deformation processes for fabrication of ultrafine grained or even nanostructured materials. Among the metallic biomaterials, commercially pure titanium exhibits the best mechanical properties, compared with other alloys. In this study, the effect of work-piece cross section on the mechanical properties of commercially pure titanium produced by this process has been investigated. The work-pieces in two types of cross section(square and circular) are pressed one pass in the square channel with angle 120° at room temperature and effects of cross section on the forming load, grain size, hardness, strength and toughness was studied. Finite element simulation by using the ABAQUS software has been performed for forecasting the forming load, equivalent plastic strain and investigation of effects of geometry parameters of die channel on these. The simulation results have shown good agreement with experimental results. Through analysis of results, it is found that by using the work-piece with circular cross section at equal channel angular pressing process, not only decreased the required pressing load, but also significantly improved the mechanical properties of the materials such as hardness and strength as compared to using the work-piece with square cross section.