In this paper, the experimental study of partially premixed combustion of methane and oxygen in a 5 mm mesoscale quartz reactor with 1 mm wall thickness and 5, 10, and 15 cm lengths. The partially premixed for 25%, 50%, and 75% mixing ratios paid. Experimental results including the factor of affecting flame regimes, formation range, flame dynamics, the outer wall temperature distribution of the reactor had been analyzing and reporting. The above tests were performing in an asymmetrically centered cylinder combustion chamber and a laminar flow regime. In most partial pre-mixing combustion experiments, the oscillation regime, which had an optimal heat distribution throughout the reactor, had been observed. The flame dynamics were more effect by changes in mixing ratio, reactor length, oxygen flow rate, and finally fuel flow rate (equivalence ratio). Also observed that by increasing the reactor length due to the appropriate time for homogenization of the mixture, differences in the flame formation interval were reducing in the different ratios of the pre-mixes.