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Diagnosis of cell properties to separate healthy and damaged tissues, imaging and determination of cells’ shape and different surfaces are new applications of atomic force microscopy, which have extended using of the atomic force microscopy these days. In the manipulation modeling of micro/nanoparticles, using an atomic force microscope, one of the important points, is using an appropriate and accurate contact model. Since in the 3D manipulation, micro/nanoparticle is located between the cantilever and the substrate, therefore contact theories should be divided into two parts. The first section is the contact between the substrate and micro/nanoparticle, and the other section is the contact between micro/nanoparticle and the tip of the cantilever. In this research elasticity module of the gastric cancer cells has been measured using atomic force microscopy to diagnose cancerous tissue. To do so, two Hertz and JKR contact models have been developed to extract the elasticity module. In an experimental, after isolating the cells from the gastric cancer tissue, the specimens were tested using a rectangular beam and pyramidal and spherical needles under an atomic force microscope, and the force-depth graphs were obtained. Data analysis was performed. According to obtained results, the considered cell’s elasticity module has been approximated 325±25 kPa based on the curves obtained from the comparison of experimental data from atomic force microscopy and Hertz and JKR contact theories.

Keywords: gastric cancer, atomic force microscopy, contact models, Young modulus

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