Nowadays one of the arguments that have been raised in the world of nanotechnologies is moving or manipulation nanoparticles. This discussion is important because the displacement of nanoparticles can make structurally different than what is currently available. So to achieve this goal, the atomic force microscope probe is used as manipulator. In this way, the use of nanoparticles by pulling or pushing on the surface, are displaced and brought to the desired point. If you apply too much force is needed, Nanoparticle Continued movement (sliding or rolling) after standing atomic force microscopy probes and away from the desired final. On the other hand, if the force is low, so that it can’t overcome the static friction force, Nanoparticles will be no movement. So finding the optimal force is important in nanomanipulation. In this paper, with using nanoparticle dynamic simulation, the governing equations on nanoparticle are derived and simulated during manipulation happen that they can be used to obtain the critical force and time for gold, yeast and platelets nanoparticles, in gaseous, water, alcohol, and plasma environments. By comparing the results obtained in this paper, it is concluded that the movement of particles in different biological environments starts later and by a force of higher magnitude relative to the gaseous medium.