slip factor is one of the most important parameters used in centrifugal pumps performance prediction. Knowing this parameter as a function of flow rate seems essential for off-design performance prediction. In this paper, it is intended to establish the slip factor dependence upon flow rate for a centrifugal pump using computational fluid dynamics. For this purpose, the full 3D-RANS equations in coupled with RNG k-ε turbulence model were solved for several flow rates ranging from 45% to 120% of rated condition by means of a commercial code, CFX. In the steady state, this simulation is defined by means of the multi-reference frame technique, in which the impeller is situated in the rotating reference frame, and the volute is in the fixed reference frame. The validity of the numerical model was confirmed by matching the calculated characteristic curves with the associated experimental data. It was found that there is a good coincidence between the numerical results and available experimental data of global performance, local velocity distribution and slip factors. A comparison was performed among the well-known slip models which reveals, that the slip factor variations can be predicted very well using CFD analysis.