Volume 17, Issue 3 (2017)                   Modares Mechanical Engineering 2017, 17(3): 437-445 | Back to browse issues page

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Habibnejad Korayem M, Estaji M, Homayooni A. Molecular dynamic modeling of bioparticles nanomanipulation based on AFM: investigating substrate effects. Modares Mechanical Engineering. 2017; 17 (3) :437-445
URL: http://mme.modares.ac.ir/article-15-1667-en.html
1- Prof. of Mechanical Eng. of Iran University of Science and Technology
Abstract:   (2149 Views)
To investigate the effects of drugs on viruses, interactions between proteins and inserting desirable genetic changes on DNA, precise study of biological cells is a necessary demand for nowadays. In this way, exploring mechanical properties of these particles and their mechanical behavior in different situations is needed; manipulation of bioparticles in nano scale is an important process for investigating nanoparticles behavior; because the amount of exerted force, deformation and investigating the damage possibility can provide useful information. In this paper, a molecular dynamics modeling of bioparticles nanomanipulation based on AFM has been done. Bioparticles include virus, protein and ssDNA. The main goal of this study is investigating the substrate effect on exerted force on the bioparticles and exploring damage possibility. Three types of substrates have been used, including silicon, graphene sheet and golden substrate. Widespread usage and low level interactions with other materials are the reasons of choosing these substrates. Results show that on gold substrate, the maximum manipulation force occurs and damage possibility is high. Also on graphene substrate manipulation force and deformation of particle are more than the silicon substrate.
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Article Type: Research Article | Subject: Biomechanics
Received: 2017/01/5 | Accepted: 2017/02/23 | Published: 2017/04/3

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