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Background: Nocardia as a Gram-positive bacillus with a microscopic appearance of branching hyphae can produce considerable disease in an appropriable host. N. facinica is a member of genus Nocardia that is potentially life threatening; therefore, therapy of N. farcinica infection remains difficult.
Case presentation: This study is a case  report of disseminated N. farcinica infection in a 64-year-old man with a history of pneumoconiosis with brain, lung, and skin involvement in Labbafi Nejad hospital, Tehran, IR Iran in November 2013 with a discussion about diagnosis and management of this particular patient.
Conclusion: Due to the involvement of brain, triple therapy was started with meropenem, amikacin, and linezolid.

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Tabaghat-o-Alsufiya is one of the ancient Persian texts written in the Harat area (Fifth century AD). Khwaja Abdullah Ansari was a Sufi who was preaching many people in several meetings in Harat. His sermons were written by one of his students later, which called ''Tabaghat-o-Alsufiya''. This text's analysis can show some unspoken language tips about the current dialects at that geographic area. This article has focused on Arabic language effects on language of Tabaghat. After a while of  the  presense of Arabs, arabic language for various social, scientific, religious, political and cultural reasons, influenced Persian language and the works of great Iranian writers and poets. Ansari´s book's language shows it has been influenced from Arabic language in some structure (grammar), vocabulary, phonetic and lexical features. This paper attempts to explain this subject with evidences and examples from the text. The study was done after careful reading of  Tabaghat-e-Ansari by using content analysis method.  

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"Personal pronouns" is one of the important issues in Persian grammar that most of the linguists and grammarians have dealt in their works and more or less presented a similar definition to the subject. In general, personal pronouns in Persian language and most of the related text have been applied in the same way; but with reference to the presence of some of the linguistic features in some ancient texts that are outcome of their relationships with diverse periods and geographical domains, it is possible that personal pronouns could have been used to some extent in different forms. The current paper intends to show the manner and different applications of personal pronouns in Tabaqat-al-Sufiyya, their origin and ratio of homogeneity and non-homogeneity of the book with other ancient texts. The personal pronouns in this text have often been used jointly with other texts or in certain cases different from them. Here, we primarily focuses on the usage of personal pronouns in Tabaqat-al-Sufiyya and ancient Herat dialects and remember them as "shebhe shenase". Specific usage of personal pronouns, specially "shebhe shenase" in ancient Herat dialects and Tabaghat is influenced by moderate Persian. From the point of view of its objectives, the current research is an applied in nature which has been accomplished through descriptive-analytical method after a detailed study of Tabaqat-al-Sufiyya and some other sources.

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Backgrounds: Currently, clinical details of immunosuppressed patients suffering from COVID-19 are limited. Some studies have shown no more severe diseases among them, but others have highlighted that immunosuppressed patients may have high levels of viral load and impaired immune responses. Herein, this study aimed to specifically address the symptoms, prognosis, laboratory tests, clinical course, and the outcome of SARS-CoV-2 infected immunocompromised patients at a tertiary referral center.
Materials & Methods: Clinical and laboratory information of 75 non-congenital immunosuppressed patients with COVID-19 disease was obtained at a referral center for immunodeficiency diseases and infectious disorders in Tehran, Iran. Three groups of immunocompromised patients were evaluated, including patients with a history of organ transplantation, autoimmune patients receiving medical therapy, and cancer patients undergoing chemotherapy.
Findings: Among 75 immune-deficient patients with COVID-19, there were 32 patients with a kidney transplant, 23 patients with malignancies, and 19 patients with autoimmune disorders. One patient had both malignancy and multiple sclerosis. The mean length of hospitalization was 10.82 days. By the end of the study, 24 (32%) patients were dead, and 51 (68%) patients were discharged. Dyspnea was the most common (64%) symptom. Low levels of O2 saturation and lymphopenia at admission time significantly affected the mortality rate of patients.
Conclusion: This study showed that mortality rate among immunocompromised patients was 32%. It seems that COVID-19 has a worse outcome and a more severe clinical course in immunocompromised patients regardless of age, gender, and underlying diseases.

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Simulation Modeling is Useful Tools to Analyze and Evaluate the Dynamic Behavior of the Complex Systems. In this Paper a Simulation Model Developed for Material Handling Equipment in the Sulphid Ore Process of Sarcheshmeh Open-Pit Copper Mine in Sarcheshme Kerman Province of Iran for Increase its Productivity. The Optimum Operating Setting of Sulphid ore Process of an Open-Pit Mine Is Determined Using Simulation Based Optimization Meta Modeling Approach. In the Developing Meta Model Step of this Paper, Design of Experiment (DOE) is used to Identify Critical Variable of the System by Fitting a Quadratic Polynomial Model. Absolute Relative Error (ARE) used to Verification and Validation Meta model. Validation Step Shown That Meta Model Provides Good Estimation to Simulation Results, Therefore It is Validate. Experimental Results Shown That by Using Current Situation Resources, the Optimization Simulation Model Generates Improving Monthly Throughput Rate of Production System and also Decrease Transportation Cost Up 8%.

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Gold nanoparticles (GNPs) with unique optical properties, such as easy operation and visualized assay, have a great ability to detect different types of analytes. Today, the use of gold nanoparticles has wide applications in the field of medicine and biotechnology, including the detection of microorganisms that cause contamination in water, air and food and it is considered a suitable alternative for chemical and physical methods. New technologies in the design of biosensors based on GNPs provide the ability to identify biological compounds accurately and quickly. One of these technologies is a detection sensor based on surface plasmon resonance (SPR), which based on its optical properties, is capable of very sensitive and specific measurement of biomolecule interactions without time delay. This technology can quantify in a short time the properties of biomolecular mediators (such as oligonucleotides, proteins and bacteria) on the surface, including reaction speed, tendency and concentration of surface mediators. In this review, while investigating the surface plasmon properties of gold nanoparticles, the simple diagnostic applications of gold nanoparticles based on the localized surface plasmon (LSPR) method and detection in biomedicine.

 

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In this paper, the buckling of rectangular plates subjected to non-uniform in-plane loading is investigated. At first the equilibrium equations of plate based on the first order shear deformation theory have been extracted. The kinematic relations have been assumed based on the von-Karman model and the Hook’s law has been considered as the constitutive equations. The adjacent equilibrium method has been used for deriving the stability equations. The equilibrium equations which are related to the prebuckling stress distribution, have been solved using the differential equations theory. To determine the buckling load of a simply supported plate, the Galerkin method has been used for solving the stability equations which are a system of differential equations with variable coefficients. In this paper, four types of in-plane loading, including the uniform, parabolic, cosine and triangular loading, have been considered and the effects of the plate aspect ratio and thickness on the buckling load has been investigated and the results have been compared with the finite element method and the classical plate theory. The comparison of the results show that for all loading cases, the buckling load computed by the classical plate theory is higher than the value obtained based on first order shear deformation theory.

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Optimum utilization of animal protein byproducts results in the use of maximum production capacity in existing processing plants. The purpose of this research was to develop a new and ready-to-eat product from fish mince and chicken protein isolate with desirable sensory characteristics by using the D-optimal Mixture Design, Quantitative Anatomical Analysis (QDA), and Principal Components Analysis (PCA ). Initially, 13 prototypes containing different percentages of fish mince and chicken protein isolate (totaling 70% of the product formulation) were prepared. After sensory evaluation by QDA method, a prototype was selected as the optimum treatment, which included 50% fish mince and 20% chicken protein isolate and 30% other ingredients. The sensory stability of the optimum prototype was investigated in comparison with the control treatment during 90 days of frozen storage. Physicochemical analysis (pH, TVB-N, PV and TBARS) and microbial tests were also used to investigate the qualitative changes of the prototypes. The results showed that the optimum prototype had better sensory and quality indexes than the control sample. This study introduces chicken protein isolate as a new food ingredients. It also emphasizes the use of a combination application of QDA and PCA analysis and the D-optimal Mixture Design model in designing and manufacturing a product with the optimal formulation. Because these data will be applicable and valid for industrial scale production.

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After parturition, inflammation of the reproductive tract in cows is common because of bacterial contamination of the uterine lumen. To investigate the beneficial effects of dietary Conjugated Linoleic Acid (CLA) supplementation on health status mediated by change in pro- and anti-inflammatory cytokine genes expression, endometrial samples were collected from Holstein cows with similar parturition date and reproductive records. From day 21 before calving to day 42 after calving, cows were fed isonitrogenous, isocaloric, and isolipidic diets that differed only in the source of fats. Cows were fed diets supplemented with palm oil as control group (saturated FA; n= 8), and CLA for the treatments, and the rate of each fat in any diet was 75 g d^-1. CLA-supplemented diet was provided with a mixture of trans-10, cis-12 CLA and cis-9, trans-11 CLA isomer. Rumen protected CLA provided 10 g d^-1 each of trans-10, cis-12 CLA and cis-9, trans-11 CLA isomers. Uterine endometrial biopsies were collected at days 21 and 42 after calving and were prepared to determine pro-inflammatory [including Tumor Necrosis Factor-α (TNFα), InterLeukins (IL-1, IL-6, IL-8) and InterFeron-gamma (IFN-γ)] and anti-inflammatory [interleukin 10 (IL-10)] cytokine genes expression. Results showed that dietary CLA supplementation decreased the expression of IL-1 and IL-8 at days 21 (respectively, 1.8 and 3.9 fold) and 42 (respectively, 4 and 104 fold) postpartum and increased expression of IL-10 at days 21 and 42 (respectively, 9.7 and 2.5 fold). The TNFα expression significantly decreased in day 21 in CLA groups compared with palm (2.5 fold). There was no difference between groups for IL-6 expression. IFN-γ expression decreased in day 21 (3.0 fold) and, conversely, increased in day 42 (2.5 fold) in CLA group compared to palm. Our results showed that, during transition period, dietary supplementation with CLA reduced inflammatory processes via inhibiting pro-inflammatory cytokines and stimulating anti-inflammatory cytokines.
 

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This study was conducted with the aim of investigating the composite of biodegradable polymers and nanoparticles in hydrogels in the form of a review article. Biodegradable polymer composites with nanoparticles in hydrogels is an advanced research field that combines the accumulation of new technologies in the field of biodegradable polymers and nanomaterials. These composites are created by integrating biodegradable polymers, which decompose naturally and reduce the harmful effects on the environment, with nanoparticles in hydrogels. The presence of nanoparticles in the structure of these composites has improved the mechanical, electrical, and thermal properties and made these compounds as multifunctional materials with wide applications in the fields of food industry, packaging, medicine, environment, and electronics. Hydrogel, as the main matrix of these composites, guarantees the ability of absorbing water and the controlled transfer of active substances. These advances are important not only in the field of science and engineering, but also in making sustainable solutions for future technologies.
 

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According to scholars of higher education in Iran, a considerable part of Iran's higher education system problems is because of ineffectiveness of decisions and policies of this sector and its non-reliance on scientific and empirical evidence. Open data policy making, as a new concept which considers using public participation in public policy making, can provide scientific and rational backing for policy optimization in Iran's higher education system. Therefore, this mixed approach study attempts to identify requirements of open data policy making in Iran's higher education system with a qualitative approach. At the next step, it applies regression test to analyze role of identified requirements in policy optimization. Results of regression analysis showed that socio-cultural requirements, managerial requirements, political-legal requirements and technical-technological requirements respectively could explain 0.304, 0.273, 0.197 & 0.152 of dependent variable variance.

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