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Microbial quality of potable water is of the most import guidelines of the World Health Organization (WHO). One of the main concerns of water supply and distribution network problems particularly in large cities is microbial growth in the pipelines that are significant non-compliers and repeatedly detect bacteria in finished drinking-water. In Iran, chlorine is mostly used as disinfection agent in conventional chemical treatment process in water treatment plants for supplying safe drinking water. This is done to maintain a residual concentration within a water distribution system for preventing the growth of pathogenic bacteria. Therefore, to meet water quality standards, it is necessary to maintain free chlorine residuals throughout the minimum and maximum levels for various reasons. This study was conducted to examine the relationship between residual chlorine concentration, turbidity and microbial quality of water used for drinking in water distribution system of city of Semnan. Heterotrophic Plate Count (HPC) bacteria was used as an indicator for microbial quality and residual chloride concentration and turbidity were selected as the main parameters for determining correlation. In this research, for the first time Water-Gems as a comprehensive and easy-to-use water distribution modeling application bacteriological software with GIS system was employed as a tool to evaluate the microbial water quality in the network of Semnan city which is known as drawn area with limited water resources. Water-Gems is a multi-platform hydraulic and water quality modeling solution for water distribution systems with advanced interoperability, geospatial model-building, optimization, and asset management tools. For the study, all required information from water supply system such as topographical references, type and diameter of pipelines, pressure head in the system and connections were imported in the software. Then sampling points were selected and 25200 samples were made for turbidity, residual chloride concentration and HPC bacteria. The results indicated that there is high correlation between free chloride residual, turbidity and HPC which means that lower chloride concentration caused the increase in turbidity and HPC number. This information can be used to formulate a bacterial growth control strategy.

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In open channels, the distribution of velocity, shear stress and other related quantities such as the diffusion and dispersion coefficients and thus all transport processes are three-dimensional, according to the three-dimensional convection and diffusion principles. Determining the velocity distribution- as a key parameter for estimating other hydraulic parameters- has always been the subject of attention. Velocity distribution in the inner region of the flow (y0.2D). The log-Wake law is of the most accepted laws for velocity distribution in wide open channels, this law modifies the logarithmic law by adding a Wake function; but in case of narrow open channels, the log-Wake law deviates from the measured data near the free surface. Because the profile by the log-Wake law depicts the velocity which increases with the increase of distance from the bed monotonically and is not able to show the velocity negative gradient near the free surface which happens in narrow open channels. In narrow open channels, the three dimensional structure of the flow and the transport momentum from the side walls to the central zone due to strong secondary currents, causes the maximum velocity to occur below the water surface which is called velocity-dip phenomenon. The velocity dip phenomenon was first reported more than a century ago. Since that time, numerous investigations have been conducted by many researchers in order to propose new models to be able to not only describe the dip phenomenon and negative gradient of velocity near the free surface, but also to predict the position of the maximum velocity accurately and fit the experimental data throughout the whole flow depth.
This paper introduces an analytical model based on Reynolds Averaged Navier Stokes (RANS) equations and an eddy viscosity distribution, to estimate velocity distribution in turbulent fully developed flows. The proposed model is suitable for both narrow and wide open channels, and is capable of predicting the dip phenomenon. The results by the model verified with data measured in several rectangular lab channels and data collected from an actual sewer channel. Since the proposed equation for velocity distribution is dependent of Coles Wake parameter (Π), the effect of this parameter on level of accuracy and description of velocity profile as well as prediction of dip phenomenon and location of maximum velocity has been studied. Many researchers proposed different values for Coles parameter, and it seems there is no universal constant value for this parameter. In this study, the value of Coles parameter was proposed by fitting the data from different channels, based on the least error calculated in predicting the velocity profiles by the proposed model. The results show that the profiles by the model agree well with experimental data and predict the velocity-dip phenomenon; also the model provides little errors compared to measured data in the channels, which is representative of high level of accuracy in defining velocity distribution profile of the flow. The value of Coles parameter estimated for channel-sewer was less than that for lab channels.

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In this study, severe plastic deformation of 7075 aluminum alloy was investigated using a new method, based on the combination of conventional upsetting and direct extrusion. In this process, which is called repetitive upsetting-extrusion, cylindrical samples were first subjected to upsetting and were subsequently subjected to extrusion at 250 °C with various processing cycles. Die design was carried out considering the possibility of conducting both upsetting and extrusion by using a single die and the maximum of four RUE cycles were successfully performed on the samples. Finite element method was used to simulate the deformation behavior of 7075 alloy during repetitive upsetting-extrusion processing and the strain distribution was obtained for the deformed samples. The finite element simulation results correlated fairly well with the microstructural observations. Based on the simulation results, the maximum effective strain was observed at the central region of the samples. The deformation behavior and the flow pattern were discussed based on the experimental and the simulation results. In addition, the effect of applied strain on mechanical properties of processed samples was studied. Tensile strength and elongation of deformed samples increased with extending the number of repetitive upsetting-extrusion cycles.

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Objective : In the present study the effect of aqueous extract of Fumaria which is a native Iranian herb on the promastigote and amasstigot under In vitro and In vivo condition.
Materials and Methods: The aqueous extract of the plant was prepared, then it was evaluated the effect of different concentration of aqueous extract under In vitro condition on promastigotes, uninfected macrophages and macrophages infected with amastigotes by counting, MTT and Flow Cytometyry were evaluated. IC50 was calculated for promastigotes. Also, the effects of aqueous extracts of Fumaria ointment on lesions caused by Leishmani major in BALB / c mice were examined.
Results:   The calculated IC50 of Funaria extract on promastigotes after 72 h was 304.17 µg/ml. The effects of Fumaria extract showed effective limitation on lesion size. The survival rate for treated mice with Fumaria extract showed significant differences with control groups.
Conclusion: The results showed that aqueous extract of Fumaria has antileishmanial effects in vitro and invivo condition. Also aqueous extract of Fumaria showed low toxicity against macrophages than pentavalent antimonials.