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Showing 2 results for Choobineh
Optimization of oil production in water injection process using ABC and SQP algorithms employing streamline simulation technique
Mohammad Javad Choobineh, Majid Siavashi, Ali Nakhaee,
Volume 15, Issue 8 (10-2015)
Abstract
In the current study, the streamline simulation technique is used for definition of a new objective function to optimize the production rates during water injection process. The streamline simulation technique, in comparison with common numerical methods for simulation of multi-phase flow in porous media, is much faster with less computational memory requirement. This method represents the key parameter of “Time of Flight” which helps to consider complex heterogeneity of porous media in a more easy way. In order to optimization of oil production rates from reservoir, a function based on averaged time of flight has been introduced which minimization of this function can be used to have uniform fronts of water for flooding of oil. For this target, two optimization techniques; the Artificial Bee Colony (ABC) and the Sequential Quadratic Programming (SQP) method are employed to optimize the objective function and their results are compared with each other. Advantages and disadvantages of these two methods are investigated and based on their advantages, a new hybrid approach is proposed which utilizes the benefits of both techniques to converge to the optimum solution. In the hybrid approach the SQP algorithm is initialized with the ABC method. In order to validate the mathematical model, a 2D homogeneous model used for optimization. Next a 2D heterogeneous model and a 3D complex reservoir model are investigated. In all the mentioned problems, it is observed that the hybrid approach, in comparision with the two other methods, can approach the optimum point with better accuracy and speed.
Investigating role of the JAK/STAT pathway in cardiac hypertrophy induced by the interval and continuous trainings in adult male rats

Volume 22, Issue 4 (Fall 2019)
Abstract
Aims: The JAK/STAT signaling pathway is activated by an interlacing-6 family of proteins and plays a crucial role in the hypertrophy process. Also, examining the role of this pathway in cardiac physiological hypertrophy derived by endurance training was the ultimate aim of this research.
Material & Methods: 16 adult male Wistar rats (age,  weeks) were used in this research. The rats were selected at random and assigned to one of two groups: Control and endurance training groups (8 rats in each group). Endurance training groups’ rats trained 8 weeks, 5 days/week. 48 hours after the last session, the rats were euthanized. The cardiac tissue was separated and cardiac hypertrophy was measured through considering heart weight to body weight ratio, left ventricle wall thickness, and cardiomyocytes area. In addition, expression levels of CT1, gp130, JAK2, and STAT3 genes were measured by real-time PCR. Finally, the data were analyzed by the independent t-test. Differences were considered significant at p<0.05.
Findings: The endurance training group had a significant increase in the heart weight to body weight ratio compared with the control group (p≤0.0001). Moreover, analyses performed by staining with Hematoxylin Eosin, shown that the training group had significant increases in the thickness of the left ventricle (p≤0.0001). Yet, measuring expression levels of studied genes revealed that there were no significant differences between the training group and the control group expression levels (CT1: P=0.174, gp130: P=0.054, JAK2: P=0.423, STAT3: P=0.062).
Conclusion: Expression profiling in the training group performed after 8 weeks of training, revealed that the expression levels of genes involved in JAK/STAT pathway genes were not changed significantly. These findings suggest that despite the protective role, the JAK/STAT pathway may not play a crucial role in physiological cardiac hypertrophy.
 

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