Heat exchangers facilitate the transfer of heat between fluids with different temperatures. Compared with solids, most fluids have lower heat transfer coefficients and as a result, the use of high heat transfer coefficient solid particles as additives can increase the convective heat transfer coefficient of the fluid. In this study, the effect of the addition of nanoparticles to the base fluid (deionized water), application of triangular-cut twisted tapes as well as corrugation of shell and tube type heat exchangers pipes, is investigated on heat transfer values, friction coefficient variations as well as variations in performance evaluation criterion. The effects of addition of 0.7 and 1% magnesium-oxide nanoparticles on heat transfer coefficient improvements is investigated and the results of simultaneous application of magnesium-oxide water nanoparticles, corrugated pipes, and twisted tapes are compared. Comparisons against the basic conditions (deionized water without nanofluid, corrugated pipes or triangular-cut twisted tapes) indicate a 48% increase in thermal performance, a minuscule increase of 6.3% in friction coefficient and a 46% increase in the performance evaluation criterion as a result of the application of %0.7 magnesium-oxide water nanoparticles, use of corrugated pipes and triangular cut twisted tapes on the inner surface of shell and tube heat exchanger piping. Also, the application of 1% magnesium-oxide water nanofluid, and simultaneous use of corrugated pipes and triangular-cut twisted tapes on shell and tube heat exchanger piping inner surface results in a 72% increase in thermal performance, a minuscule increase of 6.9% in friction coefficient and a 70% increase in the performance evaluation criterion.