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Backgrounds: Multidrug-resistant Pseudomonas aeruginosa is known as a major opportunistic pathogen in burn patients with hospital-acquired infections. The aim of this study was to investigate antibiotic resistance and the capability of (GTG) 5-PCR (polymerase chain reaction) assay for molecular typing of P. aeruginosa strains isolated from clinical samples of hospitalized burn patients in southern Iran.
Materials & Methods: This cross-sectional research was carried out on 70 P. aeruginosa isolates collected from hospitalized burn patients in southern Iran from June 2020 to January 2021. Antimicrobial susceptibility patterns of the isolates were determined using disk diffusion method. Additionally, repetitive extragenic palindromic-PCR (rep-PCR) method was used to examine the genetic similarities among the strains.
Findings: Antimicrobial susceptibility patterns revealed that the highest antibiotic resistance was against gentamicin (95.8%), followed by imipenem (94.3%) and piperacillin–tazobactam (92.8%), while colistin was the most effective antimicrobial agent. Rep-PCR typing revealed that 60 P. aeruginosa strains were classified into 49 GTG5 types (G1-G49), which were then grouped into 12 clusters (A-L) and 10 isolates with unique banding patterns according to the 80% cut off point.
Conclusion: The present study data indicated a substantial resistance to the studied antimicrobial agents, especially the last-resort antimicrobial agents. In addition, rep-PCR analysis revealed that most of the evaluated strains had partial genetic diversity; therefore, infection control activities should be carried out to decrease the colonization of MDR P. aeruginosa isolates in the hospital setting.

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Capital structure policy is a mean to tradeoff between risk and return and many factors influencing the optimal capital structure for each company. The aim of this study is to investigate the factors affecting the capital structure of companies listed in Tehran Stock Exchange and some selected stock exchanges in the developed and developing countries, and compare these determinants in a domestic versus international setting. Determinants of capital structure, considered in this research, are in the firm and country levels. In the firm level, profitability distance from bankruptcy, size and the ratio of fixed assets to total assets are used, and in the country level, the role of country’s GDP growth and stock market development is investigated. For international companies, we used Compustat Global Vantage database and World Bank databases and for domestic companies, we used Tadbirpardaz database to collect data. The findings showed the determinants significantly effecting on capital structure in four populations: the whole world, developed countries, developing countries, and Iran. Finally, we found that the developed and developing countries profitability and the size have different effects on capital structure. Alternatively in comparison between Iran and the developed countries, size and the ration of fixed assets have different effects on capital structure.

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Application of antioxidants is a common way for retarding oxidation. Due to adverse effects of synthetic antioxidants on health, the use of natural and safe antioxidants is considered essential. Pistachio green hull is a waste product and low-cost source of phenolic compounds. The use of phenolic compounds in food formulations has some limitations. In this study, the encapsulation of Pistachio Green Hull (PGH) phenolic compounds was carried out by spray-dryer using Maltodextrin (MD) as a wall material. For this purpose, the effective factors including the inlet temperature, dilution factor, wall:core ratio, and rate of feeding were optimized. MD, PGH extract powder, and encapsulated phenolic compounds produced under optimum conditions (ME) were characterized by Scanning Electron Microscopy (SEM), FTIR, X-ray Diffractometry (XRD), and Differential Scanning Calorimetry (DSC).Under optimum conditions, the amount of phenolic compounds and the encapsulation efficiency were 32.1 mg GAE g^-1 dp and 81%, respectively. DSC results showed that the microencapsulation had improved thermal stability of phenolic compounds. The DPPH test results indicated that the antioxidant activity of the free PGH extract was 10% higher than encapsulated one (ME). Storage stability results indicated that the amount of phenolic compounds of PGH extracts and ME after 60 days storage decreased by more than 29 and 4%, respectively. The microcapsules obtained can be used in the production of functional foods and pharmaceutical products, due to their antioxidant content and presence of phenolic compounds.