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Nowadays, solid tumor modeling and simulation results are used to predict how therapeutic drugs are transported to tumor cells by blood flow through capillaries and fluid flow in tissues. This model involves processes such as fluid diffusion, convective transport in extracellular matrix, and extravasation from blood vessels. In this paper, a complete model of interstitial fluid flow in tumor and normal tissue is presented with considering multi scale of solution such as blood flow through a capillary (as the smallest scale) to interstitial flow (as the biggest scale). The advanced mathematical model is used to generate a capillary network induce by tumor with two parent vessel around the tumor for the first time. In the following, the blood flow is modeled through the network with considering the non-continuous behavior of blood rheology and adaptability of capillary diameter to hemodynamics and metabolic stimuli. This flow is simultaneously simulated with interstitial flow which is coupled to blood flow through capillary with extravascular flow. The results predict elevated interstitial pressure in tumor region and heterogeneous capillary network which are introduced as barriers to drug delivery.

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Vortex combustion chamber is the new generation of liquid propellant engines chamber, where with the help of different arrangement of injectors, an inner combustion chamber vortex flow is created. This vortex can extremely help cooling and increasing the amount of propellant components mixing in the combustion chamber so it makes it possible to create a complete combustion in a low- capacity chamber. In this research, a vortex chamber has been designed and manufactured for carrying out cold tests with water as its working fluid, in order to study impact of different parameters, including pressure drop, injector quantity and input angle, chamber diameter and the thickness of the supporting step, on the performance of this type of chambers. The designed chamber, has a great deal of capabilities such as replacement ease, change in pressure drop and injectors’ input angle and studying different supporting step’s thickness to create vortex flow. Since practical investigation of all parameters is not cost-effective, cold test has been conducted for some samples and both simulation and validation have been done for it. The simulation results and chamber performance in the tests could match very well; therefore as a result of simulation assurance, the processes and other parameters in the chamber could be studied. By doing these tests we can move toward design, manufacture and test of the main vortex combustion chamber.