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Background:Estrogens play a substantial role in the proliferation, progression and treatment of breast cancer by binding with two estrogen receptors, alpha and beta (ERα and ERβ). Resistance to endocrine therapy is a major problem in the treatment of breast cancers and, in some cases, may be related to loss of ER gene expression. We have already showed that ERα methylation occurs in high frequency and may be one of the important mechanisms for ERα gene silencing in a subset of Iranian primary sporadic breast cancers. In the other hand, the CpG Island methylation status of ERβ and the relationship between clinicopathological features and the pattern of ERβ methylation in sporadic breast cancer are still unknown, especially in Iranian women. Methods: In this study, we examined the exact role of DNA methylation in the estrogen receptors, alpha and beta genes using Combined Bisulfite Restriction enzyme Analysis (COBRA) and Methylation specific polymerase chain reaction (MSP) methods in 34 tissue and 40 peripheral white blood cells in the breast cancers. Results and Conclusions: ERα promoter methylation was identified in 29(72.5%) tissue samples and 35(87.5%) peripheral blood. Among these ERα-methylated cases, the co-occurrentmethylation of ER promoter in peripheral blood and tissue samples was evident in 25 (71.4%) patient (P=0.56). Furthermore, ERβ promoter methylation was detected in 13(32.5%) tissue samples and 4(10.0%) peripheral blood specimens. Of these ERα-methylated cases, the co-ocurrent methylation of ERβ promoter in the peripheral blood and tissue samples was evident in 1(7.7%) patient (P= 0.11). Based on COBRA analysis the percentage of DNA methylation at methylation-sensitive BstUI restriction site of the ERα promoter A ranged from 1% to 91%. The percentages at promoters A region showed a borderline associations with lymph node involvement (P=0.079, r=0.55) and a significant correlation with the grade of tumors (p= 0.27, r=0.65). No significant relation was found between ERα promoter and ERβ promoter methylation (Odds ratio =2.82, 95%, CI =0.28–28.5, P=0.36). The methylation of promoter ON was observed in only a subset of tumors without ER by IHC. In addition, we did not find any significant correlationbetween the prognostic factors such as grade, tumor size, lymph node involvement, and methylation status of this promoter. Our results indicate that methylation of ERβ promoter ON is not responsible for the loss of gene expression in of all breast tumors.

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The effect of Artemia urmiana nauplii enriched with flaxseed oil on growth performance, survival and fatty acid composition of severum, Cichlasoma severum, larvae (0.3 mg initial weight) was investigated through a completely randomized block design with two treatments, viz., (1) larvae fed with plain nauplii, (2) larvae fed with nauplii enriched with flaxseed oil, in three replications. Results of the first biometry (day18^th), showed a significantly higher survival rate in treatment 1 (81.87±0.29%) than treatment 2 (68.83±1.62%) (P<0.05), but there were no significant differences in the specific growth rates, the average weight and length gains between treatments (P>0.05). At the end of the second period of the experiment (day36_th), significant differences in growth performance and survival rate was recorded between treatment 1 (97.82 ± 1.09%) and treatment 2 (91.16± 1.34%) (P>0.05).  The larvae was also found to convert n-3fatty acids to EPA and DHA.

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Background: Salmonella typhimurium is one of the most important species of Salmonella that is intracellular parasite and attacks host mucus membrane. These bacteria can cause gastroenteritis, and their main transmission route is water, poultry, meat, egg, and raw food. The aim of this study was to detect three virulence genes associated with S. typhimurium named invA, STM4497, and fliC183 genes by Multiplex PCR method.
Materials and Methods: 183 samples of poultry were collected from food products in Zanjan (Iran) and cultured in BPW (Buffered Peptone Water) for 18 hr and at 37°C, and in RVS broth (Rappaport Vassiliadis Soya) for 6 hr at 41.5°C. After amplification of genomic DNA by Multiplex PCR method, occurrence of pathogen contamination was checked and compared with standard strain.
Results: From the total of 183 collected samples, 52(28.4%) samples were positive for S. typhimurium. The frequency of STM4497, fliC183, and invA genes were 49 (27%), 3 (2%), and 53 (29%), respectively.
Conclusion: Simultaneous detection of invA, STM4497, and fliC183 genes were recognized as a key for detection of S. typhimurium by Multiplex PCR method. 

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Infective endocarditis (IE) is a rare but serious disease with different clinical pictures. Its neurological complication is commonly mistaken in term of diagnosis and treatment. Therefore, such cases must be taken under further diagnostic imaging for searching the basic structural lesions. Known causes of these signs include cardio embolism with hemorrhagic transformation, septic embolism, or mycotic aneurysms. In this paper, our case was a patient admitted for the evaluation of local neurological complaint reason and subsequent therapy. He was found to have bacterial endocarditis after medical workup. It was diagnosed prospectively from positive tests of vegetation on Transesophageal echocardiogram and Magnetic resonance imaging (MRI) results.

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Background: Nocardia as a Gram-positive bacillus with a microscopic appearance of branching hyphae can produce considerable disease in an appropriable host. N. facinica is a member of genus Nocardia that is potentially life threatening; therefore, therapy of N. farcinica infection remains difficult.
Case presentation: This study is a case  report of disseminated N. farcinica infection in a 64-year-old man with a history of pneumoconiosis with brain, lung, and skin involvement in Labbafi Nejad hospital, Tehran, IR Iran in November 2013 with a discussion about diagnosis and management of this particular patient.
Conclusion: Due to the involvement of brain, triple therapy was started with meropenem, amikacin, and linezolid.

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Introduction: Celiac disease is an autoimmune intestinal disorder which occurs in susceptible individuals by eating gluten. Not only does gluten damages the small intestine villi in celiac patients also disrupts nutrients absorption as well. People with celiac disease are unable to tolerate the gluten protein which is present in wheat, barley, oat, and possibly rye. In this study the corn sourdough lactic acid bacteria were evaluated to produce the gluten-free bread, moreover the combination of rice and corn flour were investigated whether can improve the quality and organoleptic characteristics of bread or not.
Methods: In order to prepare corn sourdough lactic acid, Lactobacillus plantarum ATCC 20179 and Lactobacillus fermentum ATCC 9338 were used as starter cultures. The corn and rice flour were mixed with two different final concentrations of 5% and 10% of bacterial strains to evaluate their effects on nutritional value of breads. Physicochemical properties of breads  were measured including, the moisture content;  pH; Total Titratable Acidity (TTA); texture analysis; staling rate; the inhibitory activity of bacterial sourdough on bread mold growth; and organoleptic assessment of breads. All the treatments were performed independently and in triplicate. The results were statistically analyzed.
Results: The organoleptic characteristics of breads were improved in breads produced by sourdough lactic acid bacteria in compare with breads produced by rice and corn flour. The pH value of rice dough containing L. plantarum was more than corn dough containing equal ratio of L. fermentum and L. plantarum. Among the samples, the acidity of dough composed of L. plantarum/L. fermentum (1:1) was more than rice dough containing L. plantarum, corn dough containing L. fermentum. Samples with L. plantarum 10% and L. fermentum 10% showed significant differences in bread moisture compared to the other samples. For inoculated bread samples (with 5% sourdough), the required force in the third day was significantly different from the required force in the first day.
Conclusion: This study confirmed the importance of fortified breads made by sourdough lactic acid bacteria (5% and 10%) with a favorable impact on sensory and rheological characteristics of bread

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Spatial continuity particularly continuity between inside and outside is a concept that man always was looking forward to express it in architecture. It is a trait for expanding a restricted area and relating the spaces to other adjacent spaces in order to have more physical-visual or intellectual-moral motions. Although the boundaries of spaces create spatial order and specify the quality of space, on the other hand, one another trait of architecture is continuity which leads to dynamism and motion. A continuous space is opposite to a closed and interrupted one, so in such spaces there is a spatial locomotion towards horizontal and vertical axis. These motions cause transparency and mobility towards the bulk of materials such as walls and columns in a way that the paths of moving or the directions of the sight are continuous. In the field of architectural expressions, continuity has several types and in this case, one of the categories can be noticed. This classification include four cases such as Historical, Cultural–social, Natural and Spatial continuity. Any of them has its definition, but in what follows, the spatial continuity will be described in detail. Spatial continuity can be studied in four states: First, the interior and exterior; in this case, besides the continuity makes perspective expansion, it inspires the concept of «being inside». The user requires both inside and outside spaces, and also the ability to move between these two spaces. Therefore, the architect should visualize and form inside and outside as a unit concept. Second case, between two interior spaces; flexible interior space, diversity and maximize capacity of space can be achieved in this way. Third, in an interior; this kind of continuity is more understood in a large enclosed space such as a church or a mosque. The fourth state, in the space outside the building; in open spaces or urban spaces can be observed. Any interior space may have continuation in six axes. Spatial continuity can be established through some architectural features, these factors include: Transparent layers; the most important factor to create continuity between two spaces. Transparency can be made by embedding the openings, doors and windows. Axis; axis represent the directions and correlate different elements to each other. In other words, axes connect spaces like a string. Although axes can be defined in various ways, two directions are often stronger than the others because the orientation of human kind is based on the horizontal and vertical direction. Rhythm and Repetition; the most important and most tangible factors that can represent spatial continuity are rhythm and repetition. Continuation and repetition are the basis of continuity. Continuation of surfaces; shared elements between the two spaces arouses a sense of continuity to the spectator. Continuity will be well understood when the surfaces of the floor, wall or ceiling of a space stretches to another space. Intermediate space; intermediate space (the third space) is one of the main factors of continuity and sequencing of architectural elements. Although this item separate two spaces, it causes the continuation without any separation between them. In each ancient and modern architecture, new methods can be observed, trying to show spatial continuity. In modern age, progress in technology and release of Classic principals (norms) caused the best type of continuity. Modern architects reduced the confliction of inside and outside and ignored the role of walls as separator elements by eliminating the boundaries of interior space. Modern architecture incorporated inside and outside to let them form one unique continuous space, without any difference between interior and exterior space. Spatial continuity in modern architecture: In modern architecture a continuous space is created by eliminating or neglecting the role of walls (separators). Therefore, there is no difference remains between inside and outside. The boundaries have become smooth, so visual continuity and accordingly, spatial continuity arises. In other words the walls lose their existence and permanency, the conflict of inside and outside is eliminated therefore the meaning of inside is weakened. The same as universal architecture, there are some rules in ancient Iranian architecture to represent spatial continuity, however mentioning the spiritual and moral sides of continuity. Iranian architectural space include three categories from the primitive time: closed, covered and open spaces. These three mainsubspaces define the whole space. Room, as a closed space, porch (Ivan) as a semi closed one and the yard as an open space. Iranian architects always try to track the continuity between these three items in their design process. They have attempted to pass the user through the space unimpeded, promoting the idea of transparency, lightness and spatial continuity, by reducing the bulk of mass and increasing the space. Iranian architectural space can be thought of as a wavy space. Conjunction with unlimited space is created through the light and perspective expansion, and space expansion between the components. Continuity through these spaces were shown spreading natural lights, and the extension of the sceneries and perspectives. Iranian architects tried to reduce the material mass of the building body in order to achieve transparency and spiritual lightness. In this essay we are intending to study the level of effect of traditional Iranian architecture on contemporary Iranian architecture and the level of effect of modern architecture on it, and finally we will make a comparison between them. For this review, a descriptive–analytic observation is set that the criteria of comparison are the factors of spatial continuity of Iranian and modern architecture. For each architectural Style, factors that represent continuity is listed, mentioning that any of these factors can be used in which state, relating the inside and outside. So this will assort results in a set of tables for each Style. A number of public buildings, built during 50 decade till now is selected for analyzing the factors in each group. Four of them will be expounded. At last the results can be observed in a detailed table, along with, a diagram represents the percentage of each factor’s participation in indicating spatial continuity in both Iranian and modern architecture.

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Backgrounds: Currently, clinical details of immunosuppressed patients suffering from COVID-19 are limited. Some studies have shown no more severe diseases among them, but others have highlighted that immunosuppressed patients may have high levels of viral load and impaired immune responses. Herein, this study aimed to specifically address the symptoms, prognosis, laboratory tests, clinical course, and the outcome of SARS-CoV-2 infected immunocompromised patients at a tertiary referral center.
Materials & Methods: Clinical and laboratory information of 75 non-congenital immunosuppressed patients with COVID-19 disease was obtained at a referral center for immunodeficiency diseases and infectious disorders in Tehran, Iran. Three groups of immunocompromised patients were evaluated, including patients with a history of organ transplantation, autoimmune patients receiving medical therapy, and cancer patients undergoing chemotherapy.
Findings: Among 75 immune-deficient patients with COVID-19, there were 32 patients with a kidney transplant, 23 patients with malignancies, and 19 patients with autoimmune disorders. One patient had both malignancy and multiple sclerosis. The mean length of hospitalization was 10.82 days. By the end of the study, 24 (32%) patients were dead, and 51 (68%) patients were discharged. Dyspnea was the most common (64%) symptom. Low levels of O2 saturation and lymphopenia at admission time significantly affected the mortality rate of patients.
Conclusion: This study showed that mortality rate among immunocompromised patients was 32%. It seems that COVID-19 has a worse outcome and a more severe clinical course in immunocompromised patients regardless of age, gender, and underlying diseases.

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Stock market timing is a very difficult task because of the complexity of the market. Since there are various factors affecting the market and therefore it is not a simple task to predict future stock price and its trend. This paper aims to apply advanced tools and algorithms such as the artificial neural networks (ANN) to model nonlinear processes and predict future stock price and its trend. More specifically, this study explores the abilities of the ANN to enhance the effectiveness of the technical analysis indicators to predict stock trend signals. Using a sample of 50 companies in the Tehran Stock Exchange (TSE), the results indicate that the ANN is capable to predict the direction of the short term movement in the future stock price. After considering the transaction costs, the results confirm that there is not significant difference among the returns gained from the ANN method, buy and hold strategy, and the most profitable technical indicators in the market when the trend is increasing. While, the ANN model yields higher returns compared to buy and hold strategy in the market when the trend is decreasing. Nevertheless, in the case of decreasing trend, the finding confirms the trend indicators (moving averages) achieve the highest returns.

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Introduction: In the framework known as processing approach to grammar, it is argued that processing provides a full-fledged functional explanation for all syntactic phenomena including constituent ordering. Linguistic structure is simply built in a way that eases processing difficulty of sentences and results in efficiency of language use. It seems that the operation of that part of the linguistic representation system that leads to formulation of concepts utilizing lexical access procedure is governed by processing mechanisms. The processing mechanisms, as it has put forward by Hawkins (1994) are those that make it possible for humans to recognize (and produce) grammatical structure in a rapid and efficient manner. The formulator is also planned in a way that minimizes the processing load. Therefore, it appears that some ordering regularities and grammatical constraints in word order and syntactic phenomena such as movement are motivated by the flawless performance of this phase of human linguistic processor. According to performance theory and efficiency principles, constituent ordering is influenced by processing efficiency, i.e. the ordering of constituents is intended to facilitate processing.
Aim: The research aims to study the processing basis of relativisation and syntactic movement known as scrambling and the effects of grammatical weight in Persian by drawing upon evidence from self-paced reading. Adopting an online reading time paradigm, the research was aimed at studying the role of grammatical weight in likelihood of post-verbal movement and processing loads of pairs of corresponding sentences. Hypotheses: Questions increasing the motivation and triggering initiation of doing this research are how different structural configurations of sentences with identical truth condition modify processing level and if the increase of grammatical weight could result in likelihood of syntactic movement. The final questions are how the movement of grammatically heavy constituents including relative clause and scrambled constituents explained in terms of processing implications. Accordingly, four hypotheses were developed in the course of the research. 
Method: The aforesaid paradigm, as an efficient experimental technique to assess processing speed of syntactic structures, was designed by Open Sesame Software. Two sets of 24 sentences in three levels of weight (light, medium and heavy) and two structural levels (unmarked preverbal constituent and post-verbal one) were presented to 40 randomly selected Persian-speaking participants (between the ages 18 and 40) with university education.  The first set consisted of sentences containing relative clause in two configurations and the second set of pairs of scrambled (post-verbal) and unscrambled sentences. Sentences were followed by a yes/no question. Data was analyzed using SPSS and ANOVA test.
Findings: In light level, the mean reading time of sentences with canonical constituent ordering was less than those with post-verbal constituents. However, this trend got reversed by the increase of grammatical weight of the constituent subjected to scrutiny. In other word, the post-verbal movement of constituents resulted in reduction of mean reading time in medium-weight sentences. This decline was markedly more significant in heavy sentences.
Conclusion: The ordering of constituents and the likelihood of movement is highly weight-sensitive. As a conclusion, the end-weight principle as an incentive to optimize the processing efficiency was approved in Persian.
 

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The role of research in the process of economic development has been proved to be very effective and investment on research has varying effects on economic variables including value added and productivity. These impacts are of importance in industry & mine. In this paper several hypotheses are tested with the aid of various models such as Johnson & Striner, Zakazit, cobb doglas- transendental and linear models. Among them cobb doglas model has proved to be best model implying that: 1- One percent increase in per capita research expenditures in industry sectors increases per capita value added around 0/041 percent after one year. 2- The effect of physical investment of industry & mine sectors on per capita production (average per capita value added ) in these sectors is higher than research expenditure. This paper contains several parts: The first part refers to literature of the subject and examines the relevant indexes of Iran.Then it examines the trend of industrial research expenditures in Iran and some other countries and it tests relation between research expenditures and value added in industries and mines sectors. Finally it explains the problems in these sectors and provides needed proposals.

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Yeki Bud Yeki Nabud, a story collection written by Mohammad Ali Jamalzadeh (1892-1997), marks the beginning of modern short story in Iran. Along with the stories in this collection, also known as the very first attempts to write Persian short story, the foreword to this book is of prime importance in Persian literary studies and literary theory. One of the basic and yet significant concepts of this foreword is “literary democracy.” The analysis of the micro-concepts and metaphors developed in this foreword helps us analyze this particular macro-concept and hence better understand the foundation for the notion of “literary democracy.” It is also important to note to what extend this macro-concept have played a role in modern Persian literature.

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Hot wire Anemometer (CTA) can be used to measure instantaneous flow velocity with high frequency. Since the principle of opearation of CTA is based on convective cooling, determination of the air flow direction is difficult. In this Research paper, we have used two cylindrical hot-film sensors placed in parallel to determine the flow direction. The wake effect and the heat due to the upstream sensor on the downstream sensor has been used to identity the flow direction. Effect of wake and presence of the upstream sensor on the downstream sensor has been studied. The results have been used to construct a probe consisting of two parallel sensors, sepereated by 1mm distance. Performance of the probe has been evaluated at various flow angles for laminar and turbulant flows. Findings of this study show that this probe provides the best performance at ±10 flow angles.

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Objective: The LRR (leucine rich proteoglycans) is a molecular recognition motif found in proteins with some roles in cell adhesion, signal transduction, DNA repair and RNA processing. Opticin is a member of this family. Takanosu et al (2001) detected messenger RNA expression of mouse opticin in the eye, heart, brain, testis, thyroid and epididymis by dot blot hybridization. In this study, expression levels of mRNA and protein of opticin was investigated by two monoclonal antibodies which were raised against opticin peptides. By this method structure of opticin in human and mouse has been studied. Materials and Methods: Mouse tissues including, kidney, testis, liver, lung, heart, brain, muscle, spleen and eye were isolated. Opticin expression was identified at mRNA and protein levels by RT-PCR and Western blot. Results: PCR analysis revealed that opticin mRNA is expressed in all the tissues studied except for the lung. However, opticin protein was detected in all tissues analyzed. Conclusion: Expression of opticin in the adult murine tissues may suggest functions other than that of putative regulation of vitreous collagen fibrillogenesis for this molecule.

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In this article, a special duct is introduced in which, inlet water jet initiates to oscillate after a short time and it causes the velocity and pressure to oscillate regularly. Considering that there is a linear relationship between the inlet jet velocity and its oscillations frequency, the flow rate can be calculated by measuring the pressure frequency. In order to study the flow field inside the current geometry of fluidic oscillator and also to find the optimum location for sensor to detect the pressure oscillation, the unsteady turbulent Navier-Stokes equations are solved by ANSYS CFX software. Having studied the grid independency, capability of K-ε and SST turbulence models for numerical simulation of unsteady flow inside the fluidic oscillator is considered. Then, according to the peak to average ratio (PAR) criterion, the qualities of pressure signals are compared at some points, to distinguish an optimum pressure sensor position. Afterwards, a prototype of fluidic oscillator flow meter is manufactured for the first time in Iran. Using this prototype and inserting the pressure and Piezoelectric sensor at the optimum point, the numerical simulation results are validated by the experimental data. Comparison between the numerical and experimental results shows that the SST model is more suitable for this flow simulation. Finally, by performing experiments in different flows, acquiring and processing pressure signals, the flow meter characteristic diagram (inlet jet oscillations frequency- inlet jet velocity) are extracted.