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Alzheimer is the most common form of dementia. Amyloid beta peptides play a key role in the pathology of Alzheimer and the recent surveys have demonstrated that amyloid beta oligomers are the most toxic component of them. Among oligomers, considering the high durability of dimer in comparison to other kinds, it has more toxic effects. Prefoldin is a molecular chaperone which prevents accumulation of misfolded proteins. Prefoldin is demonstrated that it can also operate as a nano actuator. In this article, we investigate the interaction between the prefoldin nano actuator and dimeric pathogenic nano cargo in molecular dimensions, hence the all-atom molecular dynamic simulation in explicit solvent were performed at physiological temperature. Visualizing the results and investigating the atomic distance between nano actuator and pathogenic nano cargo revealed that two arms of six arms of prefoldin nano actuator have been able to capture cargo and during the simulation they have made hydrogen bonds. Furthermore, investigating the hydrophobic effects between the hydrophobic amino acids in the cargo and nano actuator revealed that these effects have positively affected the stability of the binding between arms and the cargo. This article introduces the prefoldin as an inhibitor factor for dimeric oligomer from amyloid beta.

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Introduction: endurance and resistance exercise and the consumption of hawthorn alone and in combination have an effect on Alzheimer's disease.This study was conducted with the aim of the effect of hawthorn consumption and exercise on the inflammatory indices of Alzheimer's rats by trimethyltin chloride (TMT).
Materials and methods: rats were randomly divided into 9 healthy control and Alzheimer's groups with interventions (control, endurance training, resistance training, combined training, hawthorn, endurance training + hawthorn, resistance training + hawthorn, combined training + hawthorn). Then Alzheimer's disease developed. performed resistance , combined ,endurance exercises every week (12 weeks). Finally, blood was taken from the inferior vena and the inflammatory variables CRP, IL-6 ,TNF-α were measured by ELISA method. The Shapiro-Wilk test was used to check the normal distribution of the data, and the one-way analysis of variance (ANOVA) was used to check the mean difference between the groups (Tukey's test). P ​​<0.05 were considered statistically significant.
Results: results showed that the induction of Alzheimer's disease induced by TMT caused a significant increase in the levels of TNF α, IL 6, CRP in the Alzheimer's control group compared to the healthy control. And 12 weeks of combined training with and without hawthorn had a significant decrease in the level of these variables compared to Alzheimer's control.
Conclusion: As a result, endurance and resistance sports along with the consumption of hawthorn lead to the reduction of some inflammatory factors in Alzheimer's rats.
 key words: Alzheimer Disease, Hawthorn
TNF-α , CRP ,  IL-6 .