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In this study, the potential of controlling engine cooling temperature has been investigated experimentally to reduce NOx emissions in heavy diesel engines. Experiments have been done on 90°C and 70°C cooling temperatures that lower temperature obtained via larger radiator and setting its thermostatic valve. Also, the effects of injection timing and the percentage cooled EGR simultaneously have been studied in order to trade-off NOx reduction and increasing other pollutants such as Soot, CO, HC and fuel economy. Experimental results which related to amount of pollutants and fuel consumption by altering the engine cooling temperature, injection timing, and the percentage of cold EGR shows that NOx emissions reduce 17% averagely also fuel consumption decreases negligible.