Proton Exchange Membrane Fuel Cells (PEMFCs) are recognized as one of the promising technologies for clean energy production due to their high efficiency, low operating temperature, and environmental compatibility. In these cells, the Membrane Electrode Assembly (MEA), as the core component, plays a crucial role in the system's performance. One of the main challenges in designing and operating this assembly is preventing the leakage of fuel and oxidant gases, which directly impacts the fuel cell's overall efficiency. This paper reviews various sealing methods for the MEA, categorizing them into four main types: direct membrane sealing (PEM), membrane sealing with a plastic frame, MEA sealing with a frame, and rigid protective frame sealing. Each method has its unique features and can effectively improve performance and extend the operational lifespan of fuel cells, depending on the design and operational requirements. The results indicate that integrated sealing structures produced through injection molding processes are suitable for mass production due to their cost-effectiveness and ease of assembly. Additionally, rigid protective frame structures, owing to their high resistance to pressure and ability to prevent membrane damage, are better suited for applications requiring higher stability. Finally, the paper provides recommendations to enhance sealing methods and improve the efficiency of membrane fuel cells