Experimental investigation of two-phase air-water flow was conducted at consecutive inclinations of a large bend (with three equal slopes in respect to each other) and including the horizontal sections of the inlet and outlet of the bend. The results show that the elongated bubble regime flows without any effect of duct inclination change and consistent for all three zones of horizontal sections of before and after the bend and the bend itself. It was also noticed, as the duct inclination decreases along the route, vortex misty flow transmits to misty annular flow at higher gas flow rates. The annular flow regime was noticed only at the first slop of the bend. Slug flow was observed at the horizontal sections upstream and downstream of the bend. The slug flow at the upstream generated by the interfacial instabilities but at the downstream formed by Taylor bubbles. Slug flow area in the flow diagram increases as liquid flow rate increase at both horizontal sections. In addition, the void fraction change rate with phases mass flow rate was considered at the duct inlet.