Cancer is a disease that begins with abnormal proliferation of cells. Genes inside each cell has issued the necessary orders to the cell. Sometimes these commands in a cell are undefined and cell has abnormal behavior and after a while some of abnormal cells can circulate in blood or change into tumors. In A numerical study was carried out on the heating effect of magnetic nanoparticles used in hyperthermia with the goal of attaining a desired rise of temperature at a particular point of location of the tumor situated inside the muscle. A numerical scheme is proposed to solve the bioheat transfer problem in a two zone tissue in spherical geometry with blood perfusion and metabolism. The analytical solution evidences the accuracy of the numerical scheme and examines the results in the literature. Bio-heat equation is used to predict the temperature rise in term of characteristics of the magnetic nanoparticles, applied magnetic field and the tissue. Results show that the strength of applied AC magnetic field has the minor effect, the volume fraction and the frequency of applied AC magnetic field has moderate effect and the diameter of nanoparticles has the major effect on the temperature rise. among materials investigated in this study, FePt has the most pronounced effect. Also, the temperature rise for a position- independent perfusion rate is larger than that found for a position-dependent perfusion rate. Likewise, the temperature rise for a temperature-dependent metabolism rate is larger than that found for a temperature-independent metabolism rate.