In this study evaporation of biodiesel droplet under different operating conditions is investigated. The model is a common droplet vaporization model for multicomponent fuels. In this model, gas phase quasi-steady equations are solved analytically and energy and species transport equation in liquid phase are solved numerically. The sub-models are modified to consider high pressure effects. Peng-Robinson equation of state is used for gas phase and phase equilibrium is determined using fugacity. Effects of pressure on the thermophysical and transport properties of gas phase are considered. Five biodiesel with different composition are studied. These biodiesel have different composition of methyl esters. Biodiesel composition has little effects on droplet lifetime and maximum difference is about 20%. It is observed that increasing ambient temperature leads to decrease in droplet lifetime and increases temperature gradient inside droplet. Ambient pressure has different effects on droplet vaporization behavior at different ambient temperature. At lower temperature environment, increasing of pressure increases the droplet lifetime while at higher temperatures droplet lifetime first increases and then decreases with pressure. Increasing initial velocity of droplet reduces the droplet lifetime. Results show that at high pressures, droplet temperature reach to values near to critical temperature and accuracy of quasi-steady approximation decreases. Radius of vapor influenced sphere increases with temperature and decreases with pressure.