The variation of wall shear stress (WSS) in the microvessels may damage the endothelial layers. It also changes the mass diffusion and sediment and may be considered as an important factor in the formation of the fatty plaques and causing heart disease. According to the importance of the issue, the aim of this paper is to study the effective parameters on the wall shear stress in microvessels. In this paper, the hybrid method, combined lattice Boltzmann and immersed boundary methods is used to simulate the red blood cell (RBC) motion in the plasma flow. It should be mentioned that red blood cell has significant effect on WSS, in this regard; the present results show that the blood rheological behavior has the important effect on WSS. The results also demonstrate the effect of stenosis severity and RBC location in different regions on wall shear stress and consequently causing heart, coronary disease. It should be noted that the presented results have been evaluated by previous numerical results for microvessels and the results show the ability of lattice Boltzmann method to simulate complex problems especially for modeling the deformable solid objects suspended in the fluid.