In this study, the double stage mixed refrigerant LNG system is investigated, which is known for having the highest efficiency among the liquefaction cycles. The main purpose is to evaluate the performance double stage mixed refrigerant LNG system of point of view effect of variations the environmental and operating conditions of feed that has not been previously discussed. Such as variable environmental conditions during liquefaction processes, temperature, pressure and feed gas composition are. To view the response of the DMR liquefaction system to these changes, system which has been designed and implemented, was selected as the base case.The Results show that with decreasing temperature and increasing pressure feed natural gas, as an advantage, specific shaft work decreases and since in this case, minimum approach temperature in heat exchangers only slightly reduced than the allowed amount 3°C therefore with accepting a safety factor less (to insignificant amount) than the optimal case, can be used of this available advantage. Also, with increasing temperature and decreasing pressure of feed natural gas, while increasing the specific shaft work as well as temperature cross occurs in heat exchangers and means to from entering of the feed natural gas in the area prevented with special controls. Also, any changes in mole fraction of natural gas components make temperature cross in heat exchangers. And due to the change of the natural gas components mole percent, during the life of the well, should over time, the refrigerant composition in the cycle is optimized regarding to new conditions.