At the core of the conventional hydro cyclone, the secondary flow is created in opposite direction of the primary flow which is adjacent the wall and causes a sink pressure on the central axis of the hydro cyclone. This low pressure zone may drag fine particles to the core and escape them from the upper section of hydro cyclone. In this research by adding a sound source at the core of the hydro cyclone, the separation performance of an acoustic hydro cyclone is studied. Then the effects of the hydro cyclone’s body tilt angle with the horizon reviewed in next step. To this end, the flow simulation carried out by the appropriate turbulent and two-phase fluid flow model selection and consequently the results validated with experimental data. The result shows the optimum strength and frequency of acoustic stimulation and the performance of conventional hydro cyclone in different tilt angles, particles diameter and inlet velocities. In addition in this study, the optimum injection velocity for any diameters which use of sound source impacts greatly on increasing the separation efficiency, is introduced. Finally, by applying a genetic algorithm with two objectives function, among all the states, the model that have the highest efficiency and lowest pressure drop is selected.