In this paper, drug coated magnetic nanoparticle delivery is numerically studied. Specific part of right foot vessel connected to the abdominal aorta is considered as target tissue. Single wire is applied as magnetic source. Buongiorno’s two-phase model is modified by adding the magnetophoresis term to the volume fraction transport equation. Governing unsteady equations with ferrohydrodynamics Kelvin force as a source term is discretized with PISO based finite volume method. Effects of the location of magnetic source and magnitude of current carrying from wire (1000, 2000, 3000, 4000 and 5000 amperes) are investigated on residence time and deposition level of drug on target tissue. Diameter and volume fraction of nanoparticles are 10 nm and 0.002, respectively. From the results, location of wire should be near and upstream the target tissue. Furthermore, by using this method deposition level of drug on target tissue can be increased by 7.5 times. Best drug delivery performance is seen for current magnitude of 2000 amperes.