Volume 20, Issue 3 (March 2020)                   Modares Mechanical Engineering 2020, 20(3): 797-806 | Back to browse issues page

‎ 20.1001.1.10275940.1398.20.3.12.3

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Imanian M, Reza Biglari F. Effect of Selective Laser Sintering 3D Printing Variables on the Breaking Force of Printed Tablets. Modares Mechanical Engineering 2020; 20 (3) :797-806
URL: http://mme.modares.ac.ir/article-15-25885-en.html
Effect of Selective Laser Sintering 3D Printing Variables on the Breaking Force of Printed Tablets
M.E. Imanian1 , F. Reza Biglari * 2
1- Manufacturing and Production Department, Mechanical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran
2- Manufacturing and Production Department, Mechanical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran , biglari@aut.ac.ir
Abstract:   (5485 Views)
In this study, a selective laser sintering 3D printer has been designed and built. 3D laser printing is one of the flexible additive manufacturing methods, which can use different powdered materials. Recently, additive manufacturing technologies have been introduced into the pharmacy, and in August 2015, they received FDA approval as the three-dimensional drug products. By using additive manufacturing in the pharmacy, controlled release, dosage tailored to the characteristics of individuals, the desired morphology of the drugs can be achieved and we move toward the personalization of the medicine. One of the important issues is to determine the properties of tablets before printing. In this paper, the effect of important variables of selective laser sintering on tablet breaking force is investigated with the aid of central composite design and modeling. Using the proposed modeling, the value of each variable can be determined so that the tablets are printed with the required breaking force. The cylindrical tablets with a diameter of 1.2 cm and a height of 3.6 mm were printed for use in the experiments. To fabricate tablets, the thermoplastic polymer, Kollicoat IR (75% polyvinyl alcohol and 25% polyethylene glycol copolymer), was used and 5% paracetamol (acetaminophen) was added. Also, some edible black color was added to increase the absorption of laser light. Laser feed rate, the percentage of the tablet infill density and percentage of the added color are the studied variables. According to the results obtained in the considered range, by increasing laser feed rate, tablet breaking force decreases, but tablet braking force increases by increasing infill density and amount of added color.
Keywords: SLS 3D Printing, Tablet Breaking Force, Central Composite Design, Thermoplastic Polymer
Full-Text [PDF 1198 kb]   (3302 Downloads)    
Article Type: Original Research | Subject: Build add-on
Received: 2018/12/1 | Accepted: 2019/07/28 | Published: 2020/03/1
References
1. Gibson I, Rosen D, Stucker B. Additive manufacturing technologies. New York: Springer; 2010. [Link] [DOI:10.1007/978-1-4419-1120-9]
2. Butler J. Using selective laser sintering for manufacturing. Assembly Automation. 2011;31(3):212-219. [Link] [DOI:10.1108/01445151111150541]
3. Choonara YE, Toit LCD, Kumar P, Kondiah PPD, Pillay V. 3D-printing and the effect on medical costs: a new era?. Expert Review of Pharmacoeconomics & Outcomes Research. 2016;16(1):23-32. [Link] [DOI:10.1586/14737167.2016.1138860]
4. Goyanes A, Buanz ABM, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. International Journal of Pharmaceutics. 2014;476(1-2):88-92. [Link] [DOI:10.1016/j.ijpharm.2014.09.044]
5. Mohamed OA, Masood SH, Bhowmik JL. Optimization of fused deposition modeling process parameters: a review of current research and future prospects. Advances in Manufacturing. 2015;3(1):42-53. [Link] [DOI:10.1007/s40436-014-0097-7]
6. Melocchi A, Parietti F, Maroni A, Foppoli A, Gazzaniga A, Zema L. Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling. International Journal of Pharmaceutics. 2016;509(1-2):255-263. [Link] [DOI:10.1016/j.ijpharm.2016.05.036]
7. Goyanes A, Martinez PR., Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. International Journal of Pharmaceutics. 2015;494(2):657-663. [Link] [DOI:10.1016/j.ijpharm.2015.04.069]
8. Goyanes A, Chang H, Sedough D, Hatton GB, Wang J, Buanz A, et al. Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. International Journal of Pharmaceutics. 2015;496(2):414-420. [Link] [DOI:10.1016/j.ijpharm.2015.10.039]
9. Fina F, Goyanes A, Gaisford S, Basit AW. Selective laser sintering (SLS) 3D printing of medicines. International Journal of Pharmaceutics. 2017;529(1-2):285-293. [Link] [DOI:10.1016/j.ijpharm.2017.06.082]
10. Adeleye OA, Femi-Oyewo MN, Odeniyi MA. The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipients. Polymers in Medicine. 2014;44(4):209-220. [Link]
11. Adeleye OA, Femi-Oyewo MN, Odeniyi MA. Effect of compression pressure on mechanical and release properties of tramadol matrix tablets. Current Issues in Pharmacy and Medical Sciences. 2015;28(2):120-125. [Link] [DOI:10.1515/cipms-2015-0057]
12. Goyanes A, Fina F, Martorana, A, Sedough D, Gaisford S, Basit AW. Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. International Journal of Pharmaceutics. 2017;527(1-2):21-30. [Link] [DOI:10.1016/j.ijpharm.2017.05.021]
13. Sandler N, Preis M. Printed drug-delivery systems for improved patient treatment. Trends in pharmacological sciences. 2016;37(12):1070-1080. [Link] [DOI:10.1016/j.tips.2016.10.002]
14. Bezerra MA, Satelli RE, Oliveira EP, Villar LS, Escaleira LA.nResponse surface methodology (RSM) as a tool for optimization in analytical chemistry. Talanta. 2008;76(5):965-977. [Link] [DOI:10.1016/j.talanta.2008.05.019]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.