The interactions between vortical structures and spherical particles or droplets is of practical issues in two-phase flows. The interactions bring major changes in the flow field particularly when coupled with particle rotation. It is observed that the heat transfer rate is significantly influenced during the time that the vortices’ cores are in the vicinity of the particle. In this paper, transient heat transfer of a rotating spherical particle interacting with a pair of vortices in incompressible and viscous flow is studied using numerical solution of the Navier-Stokes and energy equations in the range of 20≥Re≤100 and non-dimensional rotational velocities 0≤Ω≤1, by computational code which has been developed by the authors. In order to ensure the accuracy of the calculation, the results are compared with numerical data reported in the literature and good agreement between results was observed. Then the effect of circulation direction of two vortices interacting with a particle by spin on its heat transfer rate was investigated. Also distribution of heat transfer coefficient at the particle surface with separate rotation around three different axes in two cases of interacting and non-interacting with vortices is given and the results of heat transfer coefficient are presented. The results show that particle rotation for Ω≤0.5, in both presence and absence of vortices in flow field has negligible effects on the particle heat transfer rate; however, with increasing of particle spin significant effects on heat transfer coefficient has been observed that due to the circulation direction of vortices, different amounts are obtained.