Modares Mechanical Engineering

Modares Mechanical Engineering

Design, Fabrication and performance of DEP-SAW sensor for measurement of cells aggregation on a lab on chip

Author
Reza Ghayour
Manufacturing Tarbiat Modares University
Abstract
In surface acoustic wave sensors, target cells are trapped by sacrificial layer, containing antigens and antibodies. In this new idea, sacrificial layer is replaced by diectrophoresis electrodes. Fast response and not being disposable and usability for various types of cells are its advantages. In order to design and fabricate the sensor, the optimized values of effective parameters have been investigated. The behavior Love wave - which is used in this sensor - is simulated with lithium Niobate as substrate and ZnO layer as guiding layer. Two types of focus and unfocus interdigital transducer electrodes for sensor are investigated. The results of the sensitivity analysis and its relationship with the sensor displacement are presented. In graphs, results indicate that the focused circular structure is more sensitive, when the number of target cells in the fluid channel is more. The sensor was tested in 142 MHz for healthy and cancerous brain and intestinal cells. The suggested sensor has good results for measurement of cells aggregation. Wave power loss in transmission from sender to receiver ports and frequency shift are two special properties for detecting healthy and cancerous cells. Results show 80 and 90 KHz decrease in frequency and 4.99 and 6.69 dB loss decrease in cancerous cells comparing to healthy cells in brain and intestinal cells respectively. In this sensor, trapping, detecting and measurement of aggregation, happens in 5-10 second, which is an outstanding result compare to 10 – 15 minutes in conventional methods.
Keywords
SAW
Dielectrophoresis
cell
Nanowire
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Modares Mechanical Engineering
Volume 18, Issue 2
April 2018
Pages 351-358