Modares Mechanical Engineering

Modares Mechanical Engineering

The Influece of Magnetic Heat Sources on Damage of Cancerous Tissue

Authors
mahdi keyhanpour
majid ghasemi
faculty of mechanical engineering, K. N. Toosi university of technology, tehran, iran
Abstract
In this study, numerically investigated effect of magnetic heat sources (residual and hysteresis) that can be useful in hyperthermia and their effects on cancerous tissue. The governing equations of continuty, momentum, concentration, energy and Arrhenius tissue destruction equation in the form of couplings are defined, solved and investigated in the finite-element COMSOL software. For blood flow inside the cancerous capillary, non-newtonian and temperature dependent model is used. The geometric model is simulated in three dimensions, including the capillary and cancerous tissue. Thermophysical properties of blood and tissue are also temperature dependent. Results indicated that the residual heat source plays a major role in increasing the temperature of the blood and tissue and can be ignored the effect of hysteresis heat source. The residual heat source has an inverse relation to the particle size and is ineffective in the particle size above 100 nm but hysteresis heat source is directly related to the size of the nanoparticles, and for particles with a size of 150 nm, it will result in a 1 degree increase in temperature for the tissue. The increase in blood temperature for 25 nm magnetic nanoparticles with the residual heat source can lead to the most destruction in cancerous tissue. Also, the viscosity of blood has an inverse relation with the concentration of magnetic nanoparticles in the capillary wall and blood temperature.
Keywords
Heat Sources
Residual
Hysteresis
Arrhenius
Magnetic nanoparticles

Subjects

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Modares Mechanical Engineering
Volume 18, Issue 5
September 2018
Pages 163-171