Thread whirling has been used in manufacturing spine screws instead of normal threading. The main advantage of thread whirling is high-speed production along with high precision. In this method, a whirling module and tool holder with specialized inserts have been used. The mentioned module is adjusted and connected to the machine at different angles according to the geometry of the thread. In this research, the thread whirling method was conducted on four pedicle screws made of Ti6Al4V to investigate the effect of the main cutting parameters, including cutting speed and feed rate on the surface integrity and dimensional accuracy. Based on the results, the obtained tolerances of the threads were in the acceptable range. In addition, the increased cutting speed reduced the surface integrity of the threads by plowing.