Milling is one of the most important operational stages in processing the minerals. Lifters are usually used with mill liners to extend their life and to enhance the grinding and crushing efficiency. Lifters worn and consequently their dimensions change during the course of operation. These changes in dimensions have a significant influence on the overall economic performance of the mills. Therefore, it is useful to know the relationship between the mill operation and the lifter profile, and the influence of lifter wear on the change in lifter profile. The wear is influenced by a range of parameters such as: media charge level, slurry filling, slurry concentration, and mill speed. In this work, the influences of these operating parameters were investigated using a pilot mill (1000 * 500 mm). To this end, a Copper ore was used to prepare slurry at 40%, 50%, 60%, 70%, and 100% solids concentration by mass. The tests covered a range of slurry filling (U) from 0.5 to 3 with solid charge between 15% and 35% of mill volume and 3 different speeds 65%, 75% and 85% of critical speed. It is found that the mill charge and the mill speed significantly affect the wear rate. For wet condition, increase in the slurry concentration and slurry filling leads to a remarkable decrease in the amount of the wear. By increase in the feed filling (in dry condition) the wear increases too. Wear rate in wet conditions is 2-4 times of dry condition.