The existence of huge gas resource in Iran and the global demand for the replacement of fossil fuels with this cleaner energy resource has caused that the large-scale gas export becomes an interesting topic. One of the methods for large-scale gas exports is liquefaction which is done by refrigeration cycle. Considering the importance of the efficient use and the reduction in energy consumption, particularly in large energy consumers like liquefaction plants, it is imperative to optimize the refrigeration cycles used in these plants. While there have been many studies focusing on the power consumption minimization of refrigeration cycles, however, in most of these studies the performance limitations of the refrigeration cycle components have not been considered. Therefore, the results of such studies are not practical for in-use refrigeration cycles in gas refineries. The main goal of this paper is to propose a systematic method to minimize the power consumption of in-use refrigeration cycles in gas liquefaction processes by taking into account the performance limitations of refrigeration cycle components and the interactions between the refrigeration cycle and the core process. In this regard, a combination of thermodynamic viewpoints and pinch technology is used as well as considering the above mentioned limitations, to express the multi-stage refrigeration cycles’ power consumption minimization problem as a function of several independent variables. Up to 15% reduction in the specific power consumption is achieved when the proposed method are implemented on the optimization of a typical in-use three-stage refrigeration cycle, used in a propane liquefaction plant.