A simultaneously solution of interstitial fluid flow in tumor tissue and blood flow in remodeled microvascular network induced by tumor

Sefidgar, Mostafa; Bazmara, Hossein; Bazargan, Majid; Mousavi Naeenian, S. Mojtaba; Soltani, Madjid

A simultaneously solution of interstitial fluid flow in tumor tissue and blood flow in remodeled microvascular network induced by tumor

Authors

Mostafa Sefidgar ¹

Hossein Bazmara ¹

Majid Bazargan ²

S. Mojtaba Mousavi Naeenian ²

Madjid Soltani

¹ PhD Student, Department of Mechanical Engineering, K. N. T. university of technology

² Assoc. Professor, Department of Mechanical Engineering, K. N. T. university of technology, Tehran, Iran.

Abstract

Nowadays, solid tumor modeling and simulation results are used to predict how therapeutic drugs are transported to tumor cells by blood flow through capillaries and fluid flow in tissues. This model involves processes such as fluid diffusion, convective transport in extracellular matrix, and extravasation from blood vessels. In this paper, a complete model of interstitial fluid flow in tumor and normal tissue is presented with considering multi scale of solution such as blood flow through a capillary (as the smallest scale) to interstitial flow (as the biggest scale). The advanced mathematical model is used to generate a capillary network induce by tumor with two parent vessel around the tumor for the first time. In the following, the blood flow is modeled through the network with considering the non-continuous behavior of blood rheology and adaptability of capillary diameter to hemodynamics and metabolic stimuli. This flow is simultaneously simulated with interstitial flow which is coupled to blood flow through capillary with extravascular flow. The results predict elevated interstitial pressure in tumor region and heterogeneous capillary network which are introduced as barriers to drug delivery.

Keywords

Tumor

Remodeled capillary network

Interstitial fluid flow

Blood flow through capillaries